Journal: Journal of Medical Primatology

Article Title: Comparison of Laser Doppler Flowmetry With Contrast‐Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey ( Chlorocebus aethiops sabaeus )

doi: 10.1111/jmp.70059

Figure Lengend Snippet: Microbubble‐based contrast‐enhanced ultrasound (CEUS). Schematic depiction of microbubble administration to enhance the microvasculature of the placenta that includes the intervillous spaces and spiral arteries. A transient increase in the mechanical index (MI) of the ultrasound results in microbubble destruction, followed by microbubble replenishment. Analysis was performed using MATLAB, with a region of interest drawn around the entire anterior placenta, as illustrated in the ultrasound image on the far left (red tracing). A time intensity curve was then generated and fit to a monoexponential model to allow for quantification of the microvascular flux rate ( β ). AF, amniotic fluid. Created in BioRender. Cilvik, S. (2026) https://BioRender.com/pg99ksd .

Article Snippet: We performed CEUS using the GE Logiq S8 equipped with a 5–12 MHz linear array probe (GE 11L) to evaluate regional two‐dimensional placental perfusion using the commercially‐available DEFINITY (R) microbubble contrast agent (Lantheus Medical Imaging), as described extensively in the rhesus macaque placenta [ , , , , , , , , ] and illustrated in Figure .

Techniques: Generated

Journal: Medical & Biological Engineering & Computing

Article Title: Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology

doi: 10.1007/s11517-024-03262-1

Figure Lengend Snippet: Flowchart. The upper part of the figure shows the overall flowchart, and the lower part shows the detailed steps of some of the processes. Part a shows the flowchart of microbubble-based H-Scan ultrasound imaging processing, part b shows the flowchart of Casorati-SVD filtering processing, and part c shows the power Doppler imaging and the normalization and comparison part

Article Snippet: Rats were immobilized, and microbubbles (SonoVue contrast agent, Bracco Imaging, Milan, Italy) were manually infused via the tail vein at a rate of 50 μL every 30 s. Ultrasound IQ data acquisition utilized a linear transducer (L22-14v, central frequency 15.625 MHz, Vantage 256, Verasonics, USA), employing coherent compounding with five plane waves (angles, − 10°, − 5°, 0°, 5°, and 10°) at a frame rate of 1 kHz.

Techniques: Imaging, Comparison

Journal: Medical & Biological Engineering & Computing

Article Title: Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology

doi: 10.1007/s11517-024-03262-1

Figure Lengend Snippet: a Non-injected microbubble group: B-mode ultrasound images locally magnified around the white dashed lines after H-Scan processing, with results input into R, G, and B channels. Yellow dashed lines indicate the selected ROI within the tube. b Microbubble-injected group: B-mode ultrasound images locally magnified around the white dashed lines after H-Scan processing, with results input into R, G, and B channels. Yellow dashed lines indicate the selected ROI within the tube

Article Snippet: Rats were immobilized, and microbubbles (SonoVue contrast agent, Bracco Imaging, Milan, Italy) were manually infused via the tail vein at a rate of 50 μL every 30 s. Ultrasound IQ data acquisition utilized a linear transducer (L22-14v, central frequency 15.625 MHz, Vantage 256, Verasonics, USA), employing coherent compounding with five plane waves (angles, − 10°, − 5°, 0°, 5°, and 10°) at a frame rate of 1 kHz.

Techniques: Injection

Journal: Medical & Biological Engineering & Computing

Article Title: Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology

doi: 10.1007/s11517-024-03262-1

Figure Lengend Snippet: Power Doppler images of rat kidney. Eight sets of experimental data with power Doppler imaging were categorized into eight groups: a, b, c, d, e, f, g, and h. In each set of figures, label 1 at the top represents the original microbubble-only power Doppler image (the power Doppler image processed from G channel data), and label 2 at the bottom represents the power Doppler image with microbubble injection and H-scan processing (the power Doppler image processed from B channel data). The blue box represents selected background noise ROI; the green box represents selected section containing small blood vessels, and the magnified image is on the right, with the location of the blood flow circled in white

Article Snippet: Rats were immobilized, and microbubbles (SonoVue contrast agent, Bracco Imaging, Milan, Italy) were manually infused via the tail vein at a rate of 50 μL every 30 s. Ultrasound IQ data acquisition utilized a linear transducer (L22-14v, central frequency 15.625 MHz, Vantage 256, Verasonics, USA), employing coherent compounding with five plane waves (angles, − 10°, − 5°, 0°, 5°, and 10°) at a frame rate of 1 kHz.

Techniques: Imaging, Injection

Journal: Medical & Biological Engineering & Computing

Article Title: Microvascular blood flow ultrasound imaging with microbubble-based H-Scan technology

doi: 10.1007/s11517-024-03262-1

Figure Lengend Snippet: Phantom experiments for CNR comparison. The yellow box is the blood flow signal ROI, the red box is the tissue signal ROI, and the green box is the background noise signal ROI. a Non-injected microbubble group. b Microbubble-injected group. Original results are input into the G channel, low-order H-Scan results are input to the R channel, and high-order H-Scan results are input to the B channel

Article Snippet: Rats were immobilized, and microbubbles (SonoVue contrast agent, Bracco Imaging, Milan, Italy) were manually infused via the tail vein at a rate of 50 μL every 30 s. Ultrasound IQ data acquisition utilized a linear transducer (L22-14v, central frequency 15.625 MHz, Vantage 256, Verasonics, USA), employing coherent compounding with five plane waves (angles, − 10°, − 5°, 0°, 5°, and 10°) at a frame rate of 1 kHz.

Techniques: Comparison, Injection